Streptococcus pneumoniae (SPN) is a globally significant cause of meningitis, the
pathophysiology of which involves damage to the brain by both bacterial virulence factors …

Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they
support vasculature functioning, participate in tissue regeneration, and regulate blood flow …

Pericytes, recognized as mural cells, have long been described as components involved in
blood vessel formation, playing a mere supporting role for endothelial cells (ECs). Emerging …

Background Brain pericytes participate in the regulation of cerebral blood flow and the
maintenance of blood–brain barrier integrity. Because of their perivascular localization, their …

Pericytes are located around blood vessels, in close contact with endothelial cells. We
discovered that pericytes dampen pro-inflammatory endothelial cell responses. Endothelial …

Tuberculous meningitis (TBM), the most severe form of tuberculosis, causes death in
approximately 25% cases despite antibiotic therapy, and half of survivors are left with …

Background The blood-brain barrier (BBB), a highly regulated interface between the blood
and the brain, prevents blood-borne substances and pathogens from entering the CNS …

Background: Research has previously distinguished between complex post-traumatic stress
disorder (CPTSD) and PTSD, with the former including a range of disturbances in self …

While the role of dysregulated polymorphonuclear leukocyte (PMN) transmigration in septic
mediated tissue damage is well documented, strategies to mitigate aberrant transmigration …

Streptococcus pneumoniae is a common pathogen associated with community-acquired
bacterial meningitis, characterized by high morbidity and mortality rates. While vaccination …