Iron is a critical component of many cellular functions including DNA replication and repair,
and it is essential for cell vitality. As an essential element, iron is critical for maintaining …

Iron as an important element plays crucial roles in various physiological and pathological
processes. Iron metabolism behaves in systemic and cellular two levels that usually are in …

Aberrant expression of MYC transcription factor family members predicts poor clinical
outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown.
We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules …

The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type
II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in …

Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …

Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine
activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for …

Iron is an essential dietary element. However, the ability of iron to cycle between oxidized
and reduced forms also renders it capable of contributing to free radical formation, which …

New and provocative insights into the relationships between iron and cancer have been
uncovered in recent years. These include delineation of connections that link cellular iron to …