This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Aromatic amines and heterocyclic aromatic amines (HAAs) are structurally related classes of
carcinogens that are formed during the combustion of tobacco or during the high …

Considerable support exists for the roles of metabolism in modulating the carcinogenic
properties of chemicals. In particular, many of these compounds are pro-carcinogens that …

This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …

Susceptibility to colorectal cancer, one of the most common forms of cancer in the Western
world, has been associated with several environmental and dietary risk factors. Dietary …

Heteroyclic aromatic amines (HAAs) are a class of hazardous chemicals that are receiving
heightened attention as a risk factor for human cancer. HAAs arise during the cooking of …

The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes
multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its …

Catechins, major polyphenol constituents of green tea, are potent chemopreventive agents
against cancers caused by chemical carcinogens in rodents. The effects of four epicatechin …

Breast cancer is the major cause of cancer death in women worldwide. High penetrance
genes account for only 5% of cases, whereas polymorphic low penetrance genes acting in …

1. Gavage administration of the natural flavonoids tangeretin, chrysin, apigenin, naringenin,
genistein and quercetin for 2 consecutive weeks to the female rat resulted in differential …