Introduction Transmission-blocking vaccines (TBV) prevent community spread of malaria by
targeting mosquito sexual stage parasites, a life-cycle bottleneck, and will be used in …

Malaria, one of the greatest historical killers of mankind, continues to claim around half a
million lives annually, with almost all deaths occurring in children under the age of five living …

Genomic epidemiology has guided research and policy for various viral pathogens and
there has been a parallel effort towards using genomic epidemiology to combat diseases …

Abstract Background Genetic diversity in Plasmodium falciparum (P. falciparum) parasites is
a major hurdle to the control of malaria. This study monitored changes in the genetic …

During sporogony, malaria-causing parasites infect a mosquito, reproduce and migrate to
the mosquito salivary glands where they can be transmitted the next time blood feeding …

Proof-of-concept studies demonstrate that antimalarial drugs designed for human treatment
can also be applied to mosquitoes to interrupt malaria transmission. Deploying a new …

Successful infectious disease interventions can result in large reductions in parasite
prevalence. Such demographic change has fitness implications for individual parasites and …

Within-host survival and between-host transmission are key life-history traits of single-celled
malaria parasites. Understanding the evolutionary forces that shape these traits is crucial to …

Mosquito-borne diseases, in particular malaria, have a significant burden worldwide leading
to nearly half a million deaths each year. The malaria parasite requires a vertebrate host …

Abstract Background Genetic diversity in Plasmodium falciparum poses a major threat to
malaria control and elimination interventions. Characterization of the genetic diversity of P …