Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
gradual loss of memory and cognitive function, which constitutes a heavy burden on the …

The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts
directly or indirectly with several cell organelles ie, Golgi bodies, mitochondria and …

In eukaryotic cells, the endoplasmic reticulum (ER) is the cell compartment involved in
secretory protein translocation and quality control of secretory protein folding. Different …

Endoplasmic reticulum (ER) stress compromises the secretion of MUC2 from goblet cells
and has been linked with inflammatory bowel disease (IBD). Although Bifidobacterium can …

Protein folding is a complex, multisystem process characterized by heavy molecular and
cellular footprints. Chaperone machinery enables proper protein folding and stable …

Protein dyshomeostasis is the common mechanism of neurodegenerative diseases such as
Alzheimer's disease (AD). Aging is the key risk factor, as the capacity of the proteostasis …

The global burden of Alzheimer's disease (AD) is growing. Valiant efforts to develop clinical
candidates for treatment have continuously met with failure. Currently available palliative …

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of four known
kinases that respond to cellular stress by deactivating the eukaryotic initiation factor 2 α …

Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to
dementia in the elderly population. AD is associated with the buildup of β-amyloid and tau …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease involving the digestive
tract, characterized by abdominal pain, diarrhea, rectal bleeding, and so on, which can make …