Genes involved in synaptic function are enriched among those with autism spectrum
disorder (ASD)-associated rare genetic variants. Dysregulated cortical neurogenesis has …

One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes,
which may interact within shared but unknown protein complexes. Here we develop a …

Intellectual disability (ID) is a prevalent neurodevelopmental disorder characterized by
neurodevelopmental defects such as the congenital impairment of intellectual function and …

Context-dependent hyperactivity in syngap1a and syngap1b zebrafish models of SYNGAP1-related
disorder Page 1 Frontiers in Molecular Neuroscience 01 frontiersin.org Context-dependent …

Methods: We used CRISPR/Cas9 to introduce frameshift mutations in the syngap1a and
syngap1b zebrafish duplicates (syngap1ab) and validated these stable models for Syngap1 …

Background: Autosomal dominant mental retardation type 5 (MRD5), a rare
neurodevelopmental disorder (NDD) characterized by intellectual disability (ID) …

The synaptic Ras/Rap guanosine triphosphatase (GTPase)–activating protein (SynGAP)
plays substantial, albeit still elusive, roles in synaptic function. SynGAP has attracted …

One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes,
which may interact within shared but unknown protein complexes. Here we develop a …

Gene expression intersects with neural activity to produce cortical circuits during brain
development. However, the cell biological mechanisms linking gene expression to activity …

Background: Alcohol use disorder (AUD) is characterized by chronic excessive alcohol
consumption, often alternating with periods of abstinence known as alcohol withdrawal …