Attention‐deficit hyperactivity disorder (ADHD) is the most common psychiatric disorder in
children and adolescents, which is characterized by behavioral problems such as attention …

Huntington's disease is a neurodegenerative disorder caused by an expanded CAG repeat
mutation in the Huntingtin (HTT) gene. The mutation impacts neuronal protein homeostasis …

Background A robust literature supports the role of the metabotropic glutamate receptor type
5 (mGluR5) in cognitive functioning. mGluR5 is also implicated in the pathophysiology of …

Alterations in glutamatergic transmission onto developing GABAergic systems, in particular
onto parvalbumin-positive (Pv+) fast-spiking interneurons, have been proposed as …

Abstract Metabotropic glutamate receptor 5 (mGluR5) and microglial abnormalities have
been implicated in autism spectrum disorder (ASD). However, controversy exists as to …

The role of glutamate system in the etiology and pathophysiology of psychiatric disorders
has gained considerable attention in the past two decades, including dysregulation of the …

The metabotropic glutamatergic receptor subtype 5 (mGluR5) may represent a promising
therapeutic target for stress-related psychiatric disorders. Here, we describe mGluR5 …

Much of our knowledge of the endocannabinoid system in schizophrenia comes from
behavioral measures in rodents, like prepulse inhibition of the acoustic startle and open-field …

Metabotropic glutamate receptor subtype 5 (mGluR5), encoded by the GRM5 gene,
represents a compelling novel drug target for the treatment of schizophrenia. mGluR5 is a …

Subtype 5 metabotropic glutamate receptors (mGlu5) are known to play an important role in
regulating cognitive, social and valence systems. However, it remains largely unknown at …