Macrophages exposed to inflammatory stimuli including LPS undergo metabolic
reprogramming to facilitate macrophage effector function. This metabolic reprogramming …

Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood,,. Here we show …

Itaconate is one of the best examples of the consequences of metabolic reprogramming
during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle …

A striking change has happened in the field of immunology whereby specific metabolic
processes have been shown to be a critical determinant of immune cell activation. Multiple …

Recent evidence indicates that mitochondria lie at the heart of immunity. Mitochondrial DNA
acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer …

It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar
to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The …

Metabolism in immune cells is no longer thought of as merely a process for adenosine
triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of …

Metabolic reprogramming has become a key focus for both immunologists and cancer
biologists, with exciting advances providing new insights into the mechanisms underlying …