CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that all
contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in …

Multicentric Castleman's disease (MCD) describes a heterogeneous group of disorders
involving proliferation of morphologically benign lymphocytes due to excessive …

Cellular stress, particularly in response to toxic and metabolic insults that perturb function of
the endoplasmic reticulum (ER stress), is a powerful inducer of the transcription factor …

Brown adipose cells are specialized to dissipate chemical energy in the form of heat, as a
physiological defence against cold and obesity. PRDM16 (PR domain containing 16) is a …

Starting with multipotent progenitors, hematopoietic lineages are specified by lineage-
restricted transcription factors. The transcription factors that determine the decision between …

Transcription factors are master regulatory switches of differentiation, including the
development of specific hematopoietic lineages from stem cells. Here we show that mice …

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts inactive cortisone and
active cortisol. Although bidirectional, in vivo it is believed to function as a reductase …

One of the central problems facing higher animals is that cells require a continuous source
of energy; however, it is impractical for organisms to meet this need by supplying a constant …

Macrophages and microglia play crucial roles during central nervous system development,
homeostasis and acute events such as infection or injury. The diverse functions of tissue …

Eosinophils are a group of granulocytes well known for their capacity to protect the host from
parasites and regulate immune function. Diverse biological roles for eosinophils have been …