The peptidome represents the array of endogenous peptides that are present in both the
intracellular and extracellular space of the body. Peptides are constantly generated in vivo …

Background Histone post-translational modifications (PTMs) play an important role in the
regulation of the expression of genes, including those involved in cancer development and …

Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor
tyrosine kinase that transmits signals across the plasma membrane, in response to fibroblast …

Mdx mice with a spontaneous mutation in exon 23 of the Dmd gene represent the most
common model to investigate the pathophysiology of Duchenne muscular dystrophy (DMD) …

The precise regulation of synaptic integrity is critical for neuronal network connectivity and
proper brain function. Essential aspects of the activity and localization of synaptic proteins …

Clinical proteomic profiling by mass spectrometry (MS) aims at uncovering specific
alterations within mass profiles of clinical specimens that are of diagnostic value for the …

Mass spectrometry-based global proteomics experiments generate large sets of data that
can be converted into useful information only with an appropriate statistical approach. We …

Sortilin is a neuronal receptor for apolipoprotein E (apoE). Sortilin-dependent uptake of
lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into …

Motile cilia are ultrastructurally complex cell organelles with the ability to actively move. The
highly conserved central apparatus of motile 9× 2+ 2 cilia is composed of two microtubules …

Parkinson's disease (PD) is a progressive neurodegenerative disorder. It affects many
organs. Lewy bodies—a histopathological “hallmark” of PD—are detected in about 75% of …