In previous years, three‑dimensional (3D) cell culture technology has become a focus of
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …

Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …

Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain
tumor microenvironment in a reproducible and scalable system, we developed a rapid three …

Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable
biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its …

Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …

Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …

Abstract Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation
of in vivo cell-cell and cell-extracellular matrix interactions than conventional two …

Natural biomaterials are extensively used in tissue engineering due to their microstructure
interconnectivity and inherent bioactivity which mimics of natural extracellular matrix (ECM) …

In the last few decades, hyaluronic acid (HA) has become increasingly employed as a
biomaterial in both clinical and research applications. The abundance of HA in many …

Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …