This paper summarizes the several lines of experimental evidence demonstrating the ability
of the prototypic GABAB receptor agonist, baclofen, to suppress multiple alcohol-related …

Binge drinking is a dangerous pattern of behavior. We tested whether chronically
manipulating nucleus accumbens (NAc) activity (via clozapine-N-oxide (CNO) and Designer …

Binge ethanol consumption has widespread negative consequences for global public
health. Rodent models offer exceptional power to explore the neurobiology underlying and …

Background There is a serious public health need for better understanding of alcohol use
disorder disease mechanisms and for improved treatments. At this writing, only three drugs …

Preclinical research over the past several decades has demonstrated a role for the γ-
aminobutyric acidB (GABAB) receptor in alcohol use disorder (AUD). This chapter offers an …

Continuous‐flow synthesis of baclofen precursor (2) was achieved using achiral and chiral
heterogeneous catalysts in high yield with high enantioselectivity. The key steps are chiral …

Rationale Binge drinking (BD) is a widespread drinkingpattern that may contribute to
promote the development of alcohol use disorder (AUD). The comprehension of its …

Racemic baclofen [(±)-baclofen] has repeatedly been reported to suppress several alcohol-
motivated behaviors, including alcohol drinking and alcohol self-administration, in rats and …

For several decades, studies conducted to evaluate the efficacy of RS (±)‐Baclofen in the
treatment of alcohol dependence yielded contrasting results. Human and animal studies …

Rationale Genetic and non-genetic factors influence substance use disorders. Our previous
work in genetic mouse models focused on genetic factors that influence methamphetamine …