Significance: Angiogenesis, the growth of new blood vessels from existing vessels, is an
important aspect of the repair process. Restoration of blood flow to damaged tissues …

Hypertrophic scars and keloids can have significant detrimental effects on patients both
psychosocially and functionally. A careful identification of patient risk factors and a …

Keloids are pathological scars presenting as nodular lesions that extend beyond the area of
injury. They do not spontaneously regress, often continuing to grow over time. The abnormal …

Keloids are pathological scars that grow over time and extend beyond the initial site of injury
after impaired wound healing. These scars frequently recur and rarely regress. They are …

Significance: The proangiogenic mediator vascular endothelial growth factor (VEGF) plays
an important role in cutaneous wound repair. Most of the work on VEGF and wound healing …

Keloids and hypertrophic scars are benign fibrous overgrowths of scar tissue, which results
from an abnormal response to trauma. Several therapeutic modalities have been described …

Background: Intralesional corticosteroid administration (ICA) is a first-line treatment for
keloids. However, its clinical results are still highly variable and often suboptimal. Treatment …

Background Central centrifugal cicatricial alopecia (CCCA) is a primary cicatricial alopecia
that most commonly affects women of African descent. Like CCCA, fibroproliferative …

Excess scar formation after cutaneous injury can result in hypertrophic scar (HTS) or keloid
formation. Modern strategies to treat pathologic scarring represent nontargeted approaches …

Objective: Vascular endothelial growth factor (VEGF) family members are critical regulators
of tissue repair and depending on their distinct pattern of receptor specificity can also …