Recent research developments have shed light on the risk factors contributing to metabolic
complications, implicating both genetic and environmental factors, potentially integrated by …

Little information is available regarding mechanistic links between epigenetic modifications
and autoimmune diseases. It seems plausible to surmise that aberrant gene expression and …

Objective Obesity is associated with low-grade inflammation and the infiltration of immune
cells in insulin-sensitive tissues, leading to metabolic impairment. Epigenetic mechanisms …

Ankylosing spondylitis (AS) is an autoimmune disease with a chronic inflammatory arthritis.
The critical role of methylation in the biology of immunocytes has increasingly been …

Simple Summary Despite clinical success, only a limited percentage of cancer patients are
responsive to immunotherapy. Recently, gut microbiota modulation has been suggested as …

Significance: Various autoimmune syndromes are characterized by abnormalities found at
the level of tissues and cells, as well as by microenvironmental influences, such as reactive …

The immunosuppressive tumor microenvironment represents one of the main obstacles for
immunotherapy of cancer. The tumor milieu is among others shaped by tumor metabolites …

Modifications of both DNA and protein by methylation are key factors in normal T and B cell
immune responses as well as in the development of autoimmune disease. For example, the …

In the context of kidney transplantation, little is known about the involvement of natural killer
(NK) cells in the immune reaction leading to either rejection or immunological tolerance …

It is clear that lupus autoimmunity is marked by a variety of abnormalities, including those
found at a macroscopic scale, cells and tissues, as well as more microenvironmental …