Schizophrenia is a complex neuropsychiatric disorder that is associated with persistent
psychosocial disability in affected individuals. Although studies of schizophrenia have …

A number of studies have indicated that antagonists of the N‐methyl‐d‐aspartate subtypes
of glutamate receptors can cause schizophrenia‐like symptoms in healthy individuals and …

Objective: Decreased density of dendritic spines in adult schizophrenia subjects has been
hypothesized to result from increased pruning of excess synapses in adolescence. In vivo …

Background Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role
in maintaining dendritic structure through its interaction with microtubules. In schizophrenia …

Alterations in cannabinoid CB1 receptor (CB1R) are implicated in various psychiatric
disorders. CB1R participates in both depolarization induced suppression of inhibition (DSI) …

Background Impaired glutamatergic signaling is believed to underlie auditory cortex
pyramidal neuron dendritic spine loss and auditory symptoms in schizophrenia. Many …

Importance Findings from unbiased genetic studies have consistently implicated synaptic
protein networks in schizophrenia, but the molecular pathologic features within these …

Schizophrenia is a chronic disease presented with psychotic symptoms, negative symptoms,
impairment in the reward system, and widespread neurocognitive deterioration. Disruption …

Background Individuals with schizophrenia are at elevated genetic risks for comorbid
cannabis use, and often experience exacerbations of cognitive and psychotic symptoms …

Background: Altered glutamatergic neurotransmission may contribute to impaired default
mode network (DMN) function in Alzheimer's disease (AD). Among the DMN hub regions …