Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks
of AD are amyloid plaques [aggregates of amyloid beta (A)] and neurofibrillary tangles …

Mitochondrial electron transport generates the ATP that is essential for the excitability and
survival of neurons, and the protein phosphorylation reactions that mediate synaptic …

Controlled proteolysis underlies a vast diversity of protective and regulatory processes that
are of key importance to cell fate. The unique molecular architecture of the widely conserved …

The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to
the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form …

Mitochondria, which serve as the energy factories of cells, are involved in cell differentiation,
calcium homeostasis, amino acid and fatty acid metabolism and apoptosis. In response to …

Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions
as diverse as aerobic metabolism and induction of cell death. The link between Ca2+ (dys) …

The HtrA family refers to a group of related oligomeric serine proteases that combine a
trypsin-like protease domain with at least one PDZ interaction domain. Mammals encode …

Mitochondria are the major source of energy for the normal functioning of brain cells.
Increasing evidence suggests that the amyloid precursor protein (APP) and amyloid beta …

Several studies have demonstrated aberrations in the Electron Transport Complexes (ETC)
and Krebs (TCA) cycle in Alzheimer's disease (AD) brain. Optimal activity of these key …