Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Recent advances of rotavirus (RV) basic and applied research are reviewed. They consist of
determination of the RV particle structure and functions of structural proteins, classification …

RNA viruses induce the formation of subcellular organelles that provide microenvironments
conducive to their replication. Here we show that replication factories of rotaviruses …

Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …

Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …

The endoplasmic reticulum (ER) is the largest intracellular organelle. It forms a complex
network of continuous sheets and tubules, extending from the nuclear envelope (NE) to the …

Viruses reshape the organization of the cell interior to achieve different steps of their cellular
cycle. Particularly, viral replication and assembly often take place in viral factories where …

Background Sabizabulin is an oral, novel microtubule disruptor that has dual antiviral and
anti-inflammatory activities in preclinical models. Methods A randomized, multicenter …

Rotaviruses (RVs) are non-enveloped multilayered dsRNA viruses that are major etiologic
agents of diarrheal disease in humans and in the young in a large number of animal …

Microtubules (MTs) form a rapidly adaptable network of filaments that radiate throughout the
cell. These dynamic arrays facilitate a wide range of cellular processes, including the …