Muscle wasting: emerging pathways and potential drug targets

A Domaniku, SN Bilgic, S Kir - Trends in Pharmacological Sciences, 2023 - cell.com
Muscle wasting is a serious comorbidity associated with many disorders, including cancer,
kidney disease, heart failure, and aging. Progressive loss of skeletal muscle mass …

Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia

M Ferrer, N Mourikis, EE Davidson, SO Kleeman… - Cell metabolism, 2023 - cell.com
Glucose dependency of cancer cells can be targeted with a high-fat, low-carbohydrate
ketogenic diet (KD). However, in IL-6-producing cancers, suppression of the hepatic …

Cancer-induced systemic pre-conditioning of distant organs: Building a niche for metastatic cells

N Rabas, RMM Ferreira, S Di Blasio… - Nature Reviews Cancer, 2024 - nature.com
From their early genesis, tumour cells integrate with the surrounding normal cells to form an
abnormal structure that is tightly integrated with the host organism via blood and lymphatic …

Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice

X Yang, J Wang, CY Chang, F Zhou, J Liu, H Xu… - Nature …, 2024 - nature.com
Cancer cachexia is a systemic metabolic syndrome characterized by involuntary weight loss,
and muscle and adipose tissue wasting. Mechanisms underlying cachexia remain poorly …

A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution

Y Zhang, M Dos Santos, H Huang, K Chen, P Iyengar… - Cell reports, 2024 - cell.com
Cancer cachexia is a prevalent and often fatal wasting condition that cannot be fully
reversed with nutritional interventions. Muscle atrophy is a central component of the …

GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia

X Chen, Q Wu, W Gong, S Ju, J Fan, X Gao… - … and Targeted Therapy, 2024 - nature.com
Abstract Cachexia, which affects 50–80% of cancer patients, is a debilitating syndrome that
leads to 20% of cancer-related deaths. A key feature of cachexia is adipose tissue atrophy …

Activation of GPR81 by lactate drives tumour-induced cachexia

X Liu, S Li, Q Cui, B Guo, W Ding, J Liu, L Quan… - Nature …, 2024 - nature.com
Abstract Cachexia affects 50–80% of patients with cancer and accounts for 20% of cancer-
related death, but the underlying mechanism driving cachexia remains elusive. Here we …

Interactions between diet and gut microbiota in cancer

G Nakatsu, N Andreeva, MH MacDonald… - Nature Microbiology, 2024 - nature.com
Dietary patterns and specific dietary components, in concert with the gut microbiota, can
jointly shape susceptibility, resistance and therapeutic response to cancer. Which diet …

Why do patients with cancer die?

A Boire, K Burke, TR Cox, T Guise… - Nature Reviews …, 2024 - nature.com
Cancer is a major cause of global mortality, both in affluent countries and increasingly in
developing nations. Many patients with cancer experience reduced life expectancy and …

Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction

Y Miao, L Xie, J Song, X Cai, J Yang, X Ma… - Physiological …, 2024 - Wiley Online Library
Sarcopenia is a systemic skeletal muscle disease characterized by a decline in skeletal
muscle mass and function. Originally defined as an age‐associated condition, sarcopenia …