1, 2, 4-Triazoles: A review of synthetic approaches and the biological activity

S Maddila, R Pagadala… - Letters in Organic …, 2013 - benthamdirect.com
1, 2, 4-Triazoles and their derivatives have a distinct place in the field of medicinal and
pharmaceutical chemistry. These are used as lead compounds for the synthesis of …

Triazole: a promising antitubercular agent

RS Keri, SA Patil, S Budagumpi… - Chemical biology & …, 2015 - Wiley Online Library
Tuberculosis is a contagious disease with comparatively high mortality worldwide. The
statistics shows that around three million people throughout the world die annually from …

Identification of potent inhibitors of NEK7 protein using a comprehensive computational approach

M Aziz, SA Ejaz, N Tamam, F Siddique, N Riaz… - Scientific reports, 2022 - nature.com
NIMA related Kinases (NEK7) plays an important role in spindle assembly and mitotic
division of the cell. Over expression of NEK7 leads to the progression of different cancers …

Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability

SK Ihmaid, SY Alraqa, MR Aouad, A Aljuhani… - Bioorganic …, 2021 - Elsevier
This study reports an efficient and convenient click chemistry synthesis of a novel series of
phthalimide scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments …

General properties and comparison of the corrosion inhibition efficiencies of the triazole derivatives for mild steel

M Faisal, A Saeed, D Shahzad, N Abbas… - Corrosion …, 2018 - degruyter.com
Mild steel (MS) corrosion is a worldwide issue that greatly affects the industrial and natural
environment. To extend the lifespan of appliances, the control of MS corrosion is necessary …

Revisiting the structure and chemistry of 3 (5)-substituted pyrazoles

A Secrieru, PM O'Neill, MLS Cristiano - Molecules, 2019 - mdpi.com
Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry,
often used as starting materials for the preparation of more complex heterocyclic systems …

Cu‐Catalysed Three‐Component Reaction of Aryldiazonium Salts with Fluorinated Diazo Reagents and Nitriles: Access to Difluoro‐ and Trifluoromethylated N1‐Aryl …

X Peng, FG Zhang, JA Ma - Advanced Synthesis & Catalysis, 2020 - Wiley Online Library
A copper‐catalysed three‐component reaction of aryldiazonium salts with fluorinated diazo
reagents and nitriles is described. This formal [1+ 2+ 2] annulation protocol provides rapid …

Asymmetric synthesis of novel triazole derivatives and their in vitro antiviral activity and mechanism of action

X Cao, W Wang, S Wang, L Bao - European Journal of Medicinal Chemistry, 2017 - Elsevier
In this study, forty-four chiral triazole derivatives have been prepared via asymmetric
synthesis, and which has been successfully characterized by typical spectroscopic …

Small molecule based five-membered heterocycles: A view of liquid crystalline properties beyond the biological applications

SY Kotian, CD Mohan, AA Merlo, S Rangappa… - Journal of Molecular …, 2020 - Elsevier
Liquid crystal (LC) is an intermediate phase of matter with the physical attributes of liquid,
and a high-level of orientational order of solids. This property of LCs has been widely …

Pyromellitic acid grafted to cross-linked LDH by dendritic units: An efficient and recyclable heterogeneous catalyst for green synthesis of 2, 3-dihydro quinazoline and …

N Ghanbari, H Ghafuri - Heliyon, 2023 - cell.com
In this work, using layered double hydroxide (LDH) inorganic substrate, melamine as
binding agent and dendrimer G1 and also pyromellitic acid (PMA) organic catalytic agent a …