Advances in diagnostic tools and therapeutic approaches for gliomas: A comprehensive review

G Thenuwara, J Curtin, F Tian - Sensors, 2023 - mdpi.com
Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical
challenges due to their invasive nature and limited treatment options. The current …

Use of microRNAs as Diagnostic, Prognostic, and Therapeutic Tools for Glioblastoma

D Valle-Garcia, V Pérez de la Cruz, I Flores… - International Journal of …, 2024 - mdpi.com
Glioblastoma (GB) is the most aggressive and common type of cancer within the central
nervous system (CNS). Despite the vast knowledge of its physiopathology and histology, its …

Therapeutically targeting the unique disease landscape of pediatric high-grade gliomas

D Fernando, AU Ahmed, BRG Williams - Frontiers in Oncology, 2024 - frontiersin.org
Pediatric high-grade gliomas (pHGG) are a rare yet devastating malignancy of the central
nervous system's glial support cells, affecting children, adolescents, and young adults …

Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma

N Mokarram, A Case, NN Hossainy, JG Lyon… - Communications …, 2025 - nature.com
The blood-brain barrier, essential for protecting the central nervous system, also restricts
drug delivery to this region. Thus, delivering drugs across the blood-brain barrier is an active …

Recurrent Glioblastoma—Molecular Underpinnings and Evolving Treatment Paradigms

C Chang, VS Chavarro, JVE Gerstl, SE Blitz… - International Journal of …, 2024 - mdpi.com
Glioblastoma is the most common and lethal central nervous system malignancy with a
median survival after progression of only 6–9 months. Major biochemical mechanisms …

When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target …

Y Aoki, M Rowland, Y Sugiyama - Frontiers in Pharmacology, 2024 - frontiersin.org
Intra-Target Microdosing (ITM), integral to Phase 0 clinical studies, offers a novel approach
in drug development, effectively bridging the gap between preclinical and clinical phases …

Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development

HM Weiss, Y Sugiyama, E van Duijn - Frontiers in pharmacology, 2024 - frontiersin.org
As part of this research topic Gundle et al describe a technology platform for intratumoral
microdosing of oncology drugs called CIVO (clinical in vivo oncology) platform. The platform …

Two-site microendoscopic imaging probe for simultaneous three-dimensional imaging at two anatomic locations in tissues

G Liu, SW Ahn, JW Kang, S Bhagavatula, D Matthew… - Optics Letters, 2024 - opg.optica.org
Systems that can image in three dimensions at cellular resolution and across different
locations within an organism may enable insights into complex biological processes, such …

Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review

J Curtin - 2023 - arrow.tudublin.ie
Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical
challenges due to their invasive nature and limited treatment options. The current …