Small extracellular vesicles derived from human adipose‐derived mesenchymal stromal cells cultured in a new chemically‐defined contaminate‐free media exhibit …

H Hanai, DA Hart, G Jacob… - Journal of …, 2023 - Wiley Online Library
Human small extracellular vesicles (sEVs) derived from adipose‐derived mesenchymal
stromal cells (ASC) have been reported to suppress the progression of osteoarthritis (OA) in …

[HTML][HTML] Advances in bone regeneration with growth factors for spinal fusion: A literature review

D Tateiwa, T Kaito - North American Spine Society Journal (NASSJ), 2023 - Elsevier
Bone tissue is regenerated via the spatiotemporal involvement of various cytokines. Among
them, the bone morphogenetic protein (BMP), which plays a vital role in the bone …

[HTML][HTML] Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion

T Furuichi, H Hirai, T Kitahara, M Bun, M Ikuta, Y Ukon… - Bioactive Materials, 2025 - Elsevier
Abstract Bone morphogenetic protein 2 (BMP2) is clinically applied for treating intractable
fractures and promoting spinal fusion because of its osteogenic potency. However, adverse …

[HTML][HTML] Basic fibroblast growth factor promotes meniscus regeneration through the cultivation of synovial mesenchymal stem cells via the CXCL6–CXCR2 pathway

A Goshima, Y Etani, M Hirao, S Yamakawa… - Osteoarthritis and …, 2023 - Elsevier
Objective To investigate the efficacy of basic fibroblast growth factor (bFGF) in promoting
meniscus regeneration by cultivating synovial mesenchymal stem cells (SMSCs) and to …

A synthetic retinoic acid receptor γ antagonist (7C)-loaded nanoparticle enhances bone morphogenetic protein-induced bone regeneration in a rat spinal fusion model

D Tateiwa, M Iwamoto, J Kodama, Y Ukon, H Hirai… - The Spine Journal, 2024 - Elsevier
BACKGROUND CONTEXT Bone morphogenetic proteins (BMPs) have potent
osteoinductivity and have been applied clinically for challenging musculoskeletal conditions …

[HTML][HTML] Effect of recombinant human bone morphogenetic protein-2 and osteoprotegerin-Fc in MC3T3-E1 cells

SH Kim, HJ Choi, SM Lee, DS Yoon… - Journal of Rheumatic …, 2024 - ncbi.nlm.nih.gov
Objective We compared the osteoblastogenesis by serially administrating recombinant
human bone morphogenetic protein-2 (rhBMP-2) and osteoprotegerin-immunoglobulin Fc …

CD1530, selective RARγ agonist, facilitates Achilles tendon healing by modulating the healing environment including less chondrification in a mouse model

D Yimiti, K Uchibe, M Toriyama, Y Hayashi… - Journal of Orthopaedic … - Wiley Online Library
Heterotopic ossification (HO) in Achilles tendon often arises due to endochondral
ossification during the healing process following trauma. Retinoic acid receptor γ (RARγ) …

Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis

T Kaito, Y Ukon, H Hirai, T Kitahara, M Bun, J Kodama… - 2023 - researchsquare.com
Recent evidence suggests an association between age-related osteoporosis and cellular
senescence in the bone; however, the specific bone cells that play a critical role in age …

[引用][C] Leveraging nuclear receptor mediated transcriptional signaling for drug discovery: Historical insights and current advances

RB Patel, SK Barnwal, AM Saleh, D Francis - 2024 - Elsevier