The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …

The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …

Chimeric antigen receptor (CAR) T cell therapy is revolutionizing cancer immunotherapy for
patients with B cell malignancies and is now being developed for solid tumors and chronic …

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …

DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …

Germline commitment following primordial germ cell (PGC) specification during early human
development establishes an epigenetic programme and competence for gametogenesis …

Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …

The molecular mechanisms and signalling pathways that regulate the in vitro preservation of
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …

It is extremely rare for a single experiment to be so impactful and timely that it shapes and
forecasts the experiments of the next decade. Here, we review how two such experiments …