ETS-domain transcription-factor networks represent a model for how combinatorial gene
expression is achieved. These transcription factors interact with a multitude of co-regulatory …

ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …

Two ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal
root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their …

The Ets family of transcription factors characterized by an evolutionarily-conserved DNA-
binding domain regulates expression of a variety of viral and cellular genes by binding to a …

The homologous ETV1, ETV4 and ETV5 proteins form the PEA3 subfamily of ETS
transcription factors. In Ewing tumors, chromosomal translocations affecting ETV1 or ETV4 …

▪ Abstract Autoinhibitory domains are regions of proteins that negatively regulate the function
of other domains via intramolecular interactions. Autoinhibition is a potent regulatory …

The E26 transformation-specific (ETS) family of transcription factors is critical for
development, differentiation, proliferation and also has a role in apoptosis and tissue …

Abstract p62 is a multifunctional cytoplasmic protein able to noncovalently bind ubiquitin and
several signaling proteins, suggesting a regulatory role connected to the ubiquitin …

Ets proteins are a family of transcription factors that regulate the expression of a myriad of
genes in a variety of tissues and cell types. This functional versatility emerges from their …

The cytokine transforming growth factor β (TGF-β) plays an important role in preventing
tumor formation by blocking cell cycle progression. Accordingly, many cancers demonstrate …