Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …

Glutathione (GSH) is the most abundant non-protein thiol present at millimolar
concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a …

Mitochondria are known to generate approximately 90% of cellular reactive oxygen species
(ROS). The imbalance between mitochondrial reactive oxygen species (mtROS) production …

Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation
of inflammatory responses is associated with most human diseases. Reactive oxygen …

Significance: Reducing equivalents (NAD (P) H and glutathione [GSH]) are essential for
maintaining cellular redox homeostasis and for modulating cellular metabolism. Reductive …

The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being …

Within living cells, mitochondria are considered relevant sources of reactive oxygen species
(ROS) and are exposed to reactive nitrogen species (RNS). During the last decade …

Chemodynamic therapy (CDT), which induces cell death by decomposing high levels of
H2O2 in tumor cells into highly toxic· OH, is recognized as a promising antineoplastic …

The transcription factor hypoxia inducible factor-1α (HIF-1α) mediates adaptive responses to
oxidative stress by nuclear translocation and regulation of gene expression. Mitochondrial …

Background Inflammation and oxidative stress play critical roles in patients with chronic
obstructive pulmonary disease (COPD). Mitochondrial oxidative stress might be involved in …