Fentanyl absorption, distribution, metabolism, and excretion: Narrative review and clinical significance related to illicitly manufactured fentanyl
Objectives This narrative review summarizes literature on pharmaceutical fentanyl's
absorption, distribution, metabolism, and excretion patterns to inform research on illicitly …
absorption, distribution, metabolism, and excretion patterns to inform research on illicitly …
[HTML][HTML] Gut microbiota disruption in hematologic cancer Therapy: molecular insights and implications for treatment efficacy
P Guevara-Ramírez, S Cadena-Ullauri… - International Journal of …, 2024 - mdpi.com
Hematologic malignancies (HMs), including leukemia, lymphoma, and multiple myeloma,
involve the uncontrolled proliferation of abnormal blood cells, posing significant clinical …
involve the uncontrolled proliferation of abnormal blood cells, posing significant clinical …
Development of an LC-MS/MS Method for ARV-110, a PROTAC Molecule, and Applications to Pharmacokinetic Studies
TTL Nguyen, JW Kim, HI Choi, HJ Maeng, TS Koo - Molecules, 2022 - mdpi.com
ARV-110, a novel proteolysis-targeting chimera (PROTAC), has been reported to show
satisfactory safety and tolerability for prostate cancer therapy in phase I clinical trials …
satisfactory safety and tolerability for prostate cancer therapy in phase I clinical trials …
Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment
D Allen, SN Hanumantharao, R McDonell, KA Irvine… - Scientific Reports, 2023 - nature.com
Inhibition of actin remodeling in nerves modulates action potential propagation and
therefore could be used to treat acute pain. N-001 is a novel protein analgesic engineered …
therefore could be used to treat acute pain. N-001 is a novel protein analgesic engineered …
Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic Diseases
C Lescop, M Birker, C Brotschi, C Burki… - Journal of Medicinal …, 2024 - ACS Publications
Piperidine 3 is a potent and selective lysophosphatidic acid receptor subtype 1 receptor
(LPAR1) antagonist that has shown efficacy in a skin vascular leakage target engagement …
(LPAR1) antagonist that has shown efficacy in a skin vascular leakage target engagement …
[HTML][HTML] Pharmacokinetic simulation and area under the curve estimation of drugs subject to enterohepatic circulation
M Alpízar, J de Jesús Reséndiz, E García Martínez… - Pharmaceutics, 2024 - mdpi.com
Enterohepatic circulation (EHC) is a complex process where drugs undergo secretion and
reabsorption from the intestinal lumen multiple times, resulting in pharmacokinetic profiles …
reabsorption from the intestinal lumen multiple times, resulting in pharmacokinetic profiles …
Combined nasal, oropharyngeal povidone iodine plus glycyrrhizic acid sprays, accelerate clinical and laboratory recovery and reduces household transmission of …
HE Elsersy, MAH Zahran, AE Elbakry… - Frontiers in …, 2022 - frontiersin.org
The COVID-19 pandemic is still posing challenging health and economic problems. Effective
broad-spectrum antiviral therapy is urgently needed for the control of early SARS-CoV-2 …
broad-spectrum antiviral therapy is urgently needed for the control of early SARS-CoV-2 …
Pharmacokinetics of isavuconazole at different target sites in healthy volunteers after single and multiple intravenous infusions
F Bergmann, M Wölfl-Duchek, A Jorda… - Journal of …, 2024 - academic.oup.com
Background Invasive aspergillosis is a severe fungal infection that affects multiple organ
systems including the CNS and the lungs. Isavuconazole, a novel triazole antifungal agent …
systems including the CNS and the lungs. Isavuconazole, a novel triazole antifungal agent …
Importance of Considering Fed-State Gastrointestinal Physiology in Predicting the Reabsorption of Enterohepatic Circulation of Drugs
K Nakamura, A Kambayashi, S Onoue - Pharmaceutical Research, 2024 - Springer
Purpose The purpose of this study was to develop a simulation model for the
pharmacokinetics (PK) of drugs undergoing enterohepatic circulation (EHC) with …
pharmacokinetics (PK) of drugs undergoing enterohepatic circulation (EHC) with …
Pharmacokinetics and Enterohepatic Circulation of 2-(Quinoline-8-carboxamido) benzoic Acid (2-QBA) in Mice
JH Jeon, SY Jeon, YJ Baek, CE Park, MK Choi… - …, 2024 - pmc.ncbi.nlm.nih.gov
The quinoline alkaloid 2-(quinoline-8-carboxamido) benzoic acid (2-QBA), which is isolated
from Aspergillus sp. SCSIO06786, a deep sea-derived fungus, has been suggested as a …
from Aspergillus sp. SCSIO06786, a deep sea-derived fungus, has been suggested as a …