Mitochondria are multifunctional and dynamic organelles deeply integrated into cellular
physiology and metabolism. Disturbances in mitochondrial function are involved in several …

Nicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate
neurotransmission. However, their widespread distribution in the human body suggests a …

Toxins present in cigarette and e-cigarette smoke constitute a significant cause of illnesses
and are known to have fatal health impacts. Specific mechanisms by which toxins present in …

Nicotine, one of the main ingredients of cigarettes, promotes activation of pancreatic stellate
cells (PSCs) and exacerbates pancreatic fibrosis in previous studies. Here we focus on the …

Parkinson's disease (PD) is one of the most prevalent and debilitating neurodegenerative
conditions, and is currently on the rise. Several dysregulated pathways are behind the …

Mitochondrial dysfunction is a predominant risk factor in ischemic heart disease, in which the
imbalance of mitochondrial fusion and fission deteriorates mitochondrial function and might …

Classical metabolomic and new metabolic network methods were used to study the
developmental features of autism spectrum disorder (ASD) in newborns (n= 205) and 5-year …

Betaine is a key metabolite of the methionine cycle and known for attenuating alcoholic
steatosis in the liver. Recent studies have focused on the protection effect of betaine in …

Background: Nicotine is a behavioral stimulant that in high doses, through the neuro-
inflammatory and oxidative stress pathway, can induce apoptosis and autophagy leading to …

While various modalities of chronic nicotine use have been associated with numerous
negative consequences to human health, one possible benefit of nicotine exposure has …