High-throughput sequencing technologies are providing new insights into the genetic
alterations involved in melanomagenesis. It appears likely that most genetic events …

Confirming a diagnosis of cutaneous melanoma requires obtaining a skin biopsy specimen.
However, obtaining numerous biopsy specimens—which often happens in patients with …

Purpose: Conjunctival melanoma is a rare but potentially deadly tumor of the eye. Despite
effective local therapies, recurrence and metastasis remain frequent. Once the tumor has …

Image-based analysis as a rapid method for mutation detection can be advantageous in
research or clinical settings when tumor tissue is limited or unavailable for direct testing …

Purpose: Copy number alterations have been shown to be involved in melanoma
pathogenesis. The randomized phase III clinical trial E2603: carboplatin …

It is well demonstrated that CCND1 amplification is a frequent event in the acral subtype of
cutaneous malignant melanoma; however, its role in the other subtypes of the disease is still …

Metastatic melanoma is characterized by complex genomic alterations, including a high rate
of mutations in driver genes and widespread deletions and amplifications encompassing …

Меланома наиболее опасное злокачественное заболевание кожи человека с высоким
риском метастазирования. Метастазирующая меланома прогностически крайне …

The criterion standard for diagnosing cutaneous melanoma continues to be histologic
examination. However, classifying some melanocytic lesions by conventional microscopy …

In melanoma, the presence of promoter related hypermethylation has previously been
reported, however, no methylation-based distinction has been drawn among the diverse …