The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

A growing body of evidence indicates that obesity is strongly and independently associated
with adverse outcomes of COVID-19, including death. By combining emerging knowledge of …

Recently, attention has been focused on the central role of TREM2 in diverse pathologies.
However, the role of TREM2 signaling in the tumor microenvironment of hepatocellular …

Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested
in the diet. By modulating the activity of many proteins [eg, liver X receptors (LXRs), oxysterol …

Purpose of Review A growing body of evidence suggests that obesity and increased visceral
adiposity are strongly and independently linked to adverse outcomes and death due to …

Dendrogenin A (DDA) is a newly discovered cholesterol metabolite with tumor suppressor
properties. Here, we explored its efficacy and mechanism of cell death in melanoma and …

Colorectal cancer (CRC) is one of the most commonly occurring cancers worldwide.
Although several genetic alterations have been associated with CRC onset and …

There are a plethora of cancer causes and the road to fully understanding the
carcinogenesis process remains a dream that keeps changing. However, a list of role …

Tumor cells show high avidity for cholesterol in order to support their inherent nature to
divide and proliferate. This results in the rewiring of cholesterol homeostatic pathways by …

Liver X receptor α (LXRα), a member of the nuclear receptor superfamily, is identified as a
protein activated by ligands that interacts with the promoters of specific genes. It regulates …