Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

Abstract Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex
involved in the regulation of gene expression in metazoans. PRC2 is formed by a tetrameric …

Chronic myeloid malignancies are categorized to the three main categories
myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDSs) and MDS/MPN …

Although clinically tested JAK inhibitors reduce splenomegaly and systemic symptoms,
molecular responses are not observed in most myeloproliferative neoplasm (MPN) patients …

The myeloproliferative neoplasms are a heterogeneous group of clonal disorders
characterized by the overproduction of mature cells in the peripheral blood, together with an …

Myelodysplastic syndrome (MDS) is a heterogeneous, clonal hematological disorder
characterized by ineffective hematopoiesis, cytopenia, morphologic dysplasia, and …

The myelodysplastic syndrome (MDS) is a clonal disorder characterized by increased stem
cell proliferation coupled with aberrant differentiation resulting in a high rate of apoptosis …

Since the discovery of the JAK 2 V617F mutation in the majority of the myeloproliferative
neoplasms (MPN) of polycythemia vera, essential thrombocythemia and primary …

Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) are aggressive
myeloid malignancies recognized as a distinct category owing to their unique combination of …

The landscape of medical sequencing has rapidly changed with the evolution of next
generation sequencing (NGS). These technologies have contributed to the molecular …