Dosage compensation in Drosophila increases the transcription of genes on the single X
chromosome in males to equal that of both X chromosomes in females. Site-specific histone …

The sex chromosomes have special significance in the history of genetics. The
chromosomal basis of inheritance was firmly established when Calvin Bridges demonstrated …

Following fertilization, the genomes of the germ cells are reprogrammed to form the
totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin …

Sex-specific splicing is an essential process that regulates sex determination and drives
sexual dimorphism. Yet, how early in development widespread sex-specific transcript …

The Drosophila male-specific lethal (MSL) dosage compensation complex increases
transcript levels on the single male X chromosome to equal the transcript levels in XX …

The Drosophila male-specific lethal (MSL) complex binds to the male X chromosome to
activate transcription. It comprises five proteins (MSL1, MSL2, MSL3, male absent on the first …

X-chromosome dosage compensation by the MSL (male-specific lethal) complex is required
in Drosophila melanogaster to increase gene expression from the single male X to equal …

The Male Specific Lethal (MSL) complex provides an exquisite example of an epigenetic
modulator that is involved in chromosome-wide as well as individual gene regulation in flies …

The conserved histone locus body (HLB) assembles prior to zygotic gene activation early
during development and concentrates factors into a nuclear domain of coordinated histone …

Transcription regulators select their genomic binding sites from a large pool of similar, non-
functional sequences. Although general principles that allow such discrimination are known …