The act of defaecation, although a ubiquitous human experience, requires the coordinated
actions of the anorectum and colon, pelvic floor musculature, and the enteric, peripheral and …

Constipation is a common symptom that may be primary (idiopathic or functional) or
associated with a number of disorders or medications. Although most constipation is self …

Background Chronic constipation is a prevalent disorder that remains challenging to treat.
Studies suggest increasing fiber intake may improve symptoms, although recommendations …

It is widely accepted that the gut microbiota plays a significant role in modulating
inflammatory and immune responses of their host. In recent years, the host-microbiota …

OBJECTIVES: Tenapanor is a first-in-class, minimally absorbed, small-molecule inhibitor of
the gastrointestinal sodium/hydrogen exchanger isoform 3. This phase 3 trial assessed the …

METHODS: In this randomized double-blind study (ClinicalTrials. gov identifier:
NCT02686138), patients with IBS-C received tenapanor 50 mg bid or placebo bid for 26 …

Background & Aims Functional constipation is the most common of the disorders of gut-brain
interaction, affecting approximately 12% of the world population. Although classically …

Objective Current studies on the association between constipation and depression is still
insufficient. In this study, we investigated the detailed association between constipation and …

Constipation, a disorder of bowel movements, is among the most frequent gastrointestinal
complaints in Western countries. Dietary constituents such as inadequate fiber intake have …

Background There is mixed evidence that physical activity is associated with constipation on
the population level. This analysis aimed to determine whether amount and types of physical …