This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated
successfully with surgery alone and survival rates are high, but after metastasis survival …

The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

The interaction between histones and DNA is important for eukaryotic gene expression. A
loose interaction caused, for example, by the neutralization of a positive charge on the …

Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

In general, heterocyclic compounds are a significant source of pharmacologically active
compounds. Among them, the indole scaffold widely distributes in natural products and …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Carcinogenesis cannot be explained only by genetic alterations, but also involves
epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic …

Epigenetic drug discovery field has evidenced significant advancement in the recent times.
A plethora of small molecule inhibitors have progressed to clinical stage investigations and …