Epithelial–immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis

GM Verstappen, S Pringle, H Bootsma… - Nature Reviews …, 2021 - nature.com
In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

Clinical manifestations and early diagnosis of Sjögren syndrome

SS Kassan, HM Moutsopoulos - Archives of internal medicine, 2004 - jamanetwork.com
Sjögren syndrome (SS) is a common autoimmune disease evidenced by broad organ-
specific and systemic manifestations, the most prevalent being diminished lacrimal and …

Autoantibodies in Sjögren's syndrome

A Fayyaz, BT Kurien… - Rheumatic Disease …, 2016 - rheumatic.theclinics.com
Sjogren's syndrome is characterized by the presence of a plethora of autoantibodies (Table
1). We herein review major recent development in autoantibodies associated with Sjogren …

Sjögren's syndrome

CP Mavragani, GE Fragoulis… - The Autoimmune …, 2014 - Elsevier
Sjögren's syndrome (SjS) is a systemic autoimmune disease, characterized by the presence
of periductal lymphocytic infiltrations in salivary and lachrymal glands resulting in oral and …

[HTML][HTML] Dry eye–induced conjunctival epithelial squamous metaplasia is modulated by interferon-γ

CS De Paiva, AL Villarreal, RM Corrales… - … & visual science, 2007 - arvojournals.org
purpose. To investigate the role of interferon (IFN)-γ in the pathogenesis of conjunctival
squamous metaplasia in dry eye. methods. Experimental dry eye was created by subjecting …

Pathogenesis of Sjögren's syndrome: what we know and what we should learn

AG Tzioufas, EK Kapsogeorgou… - Journal of autoimmunity, 2012 - Elsevier
Sjögren's syndrome (SS) or autoimmune epithelitis is a prototype autoimmune disorder with
unique features: a broad clinical spectrum that extends from local exocrinopathy to systemic …

T cells in primary Sjögren's syndrome: targets for early intervention

GM Verstappen, FGM Kroese, H Bootsma - Rheumatology, 2021 - academic.oup.com
A histologic hallmark of primary SS (pSS) is lymphocytic infiltration of the salivary and
lacrimal glands, in particular by CD4+ T and B cells. In the early stages of the disease …

The role of intrinsic epithelial activation in the pathogenesis of Sjögren's syndrome

MN Manoussakis, EK Kapsogeorgou - Journal of autoimmunity, 2010 - Elsevier
Sjögren's syndrome (SS) is a chronic autoimmune disorder that is characterized by
dysfunction and destruction of the exocrine glands. Exocrinopathy is associated with …

Immunobiology of T cells in Sjögren's syndrome

Y Yao, JF Ma, C Chang, T Xu, CY Gao… - Clinical Reviews in …, 2021 - Springer
Sjögren's syndrome (SjS) is a systemic autoimmune disease marked by xerostomia (dry
mouth), keratoconjunctivitis sicca (eye dryness), and other systematic disorders. Its …

Rates of infiltration by macrophages and dendritic cells and expression of interleukin‐18 and interleukin‐12 in the chronic inflammatory lesions of Sjögren's syndrome …

MN Manoussakis, S Boiu… - … : Official Journal of …, 2007 - Wiley Online Library
Objective. To evaluate the expression profile of infiltrating macrophages and dendritic cells
(DCs) as well as of interleukin-18 (IL-18) and IL-12 in the minor salivary gland (MSG) lesions …