Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies
BACKGROUND The microtubule-associated protein tau has been implicated in the
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …
Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
Self-organizing 3D human neural tissue derived from induced pluripotent stem cells recapitulate Alzheimer's disease phenotypes
The dismal success rate of clinical trials for Alzheimer's disease (AD) motivates us to
develop model systems of AD pathology that have higher predictive validity. The advent of …
develop model systems of AD pathology that have higher predictive validity. The advent of …
[HTML][HTML] ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
Frontotemporal dementia (FTD) because of MAPT mutation causes pathological
accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We …
accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We …
Glucocerebrosidase and its relevance to Parkinson disease
J Do, C McKinney, P Sharma, E Sidransky - Molecular neurodegeneration, 2019 - Springer
Mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, are
among the most common known genetic risk factors for the development of Parkinson …
among the most common known genetic risk factors for the development of Parkinson …
Atypical, non-standard functions of the microtubule associated Tau protein
Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago,
most studies have focused on Tau's role in microtubule stability and regulation, as well as on …
most studies have focused on Tau's role in microtubule stability and regulation, as well as on …
Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease
The relationship between amyloid-β (Aβ) species and tau pathology in Alzheimer's disease
(AD) is not fully understood. Here, we provide direct evidence that Aβ42/40 ratio, not total Aβ …
(AD) is not fully understood. Here, we provide direct evidence that Aβ42/40 ratio, not total Aβ …
Tau oligomers neurotoxicity
G Niewiadomska, W Niewiadomski, M Steczkowska… - Life, 2021 - mdpi.com
Although the mechanisms of toxic activity of tau are not fully recognized, it is supposed that
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …
Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies
Abstract See Josephs (doi: 10.1093/brain/awx367) for a scientific commentary on this article.
In many neurodegenerative disorders, familial forms have provided important insights into …
In many neurodegenerative disorders, familial forms have provided important insights into …
Propagation of Tau aggregates
M Goedert, MG Spillantini - Molecular brain, 2017 - Springer
Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small
number of brain cells, from where they propagate to other regions, resulting in …
number of brain cells, from where they propagate to other regions, resulting in …