▪ Abstract The protein kinase Akt/PKB is activated via a multistep process by a variety of
signals. In the early steps of this process, PI-3 kinase-generated D3-phosphorylated …

Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …

Gradients of PtdIns4 P between organelle membranes and the endoplasmic reticulum (ER)
are thought to drive counter-transport of other lipids via non-vesicular traffic. This novel …

One of the “simple” curiosities of life, at least for a biological scientist, is how the growth and
development of a complete organism from a single cell is controlled. Part of the answer …

Synaptojanin is a polyphosphoinositide phosphatase that is found at synapses and binds to
proteins implicated in endocytosis. For these reasons, it has been proposed that …

Phosphoinositide plays a critical role not only in generating second messengers, such as
inositol 1, 4, 5-trisphosphate and diacylglycerol, but also in modulating a variety of cellular …

Phosphoinositides have been implicated in synaptic vesicle recycling largely based on
studies of enzymes that regulate phosphoinositide synthesis and hydrolysis. One such …

Abstract Synaptojanin 1 is an inositol 5′‐phosphatase highly enriched in nerve terminals
with a putative role in recycling of synaptic vesicles. We have previously described …

In yeast two-hybrid screens for proteins that bind to SNAP-25 and may be involved in
exocytosis, we isolated a protein called EHSH1 (for EH domain/SH3 domain-containing …

Phosphoinositides are essential signaling molecules linked to a diverse array of cellular
processes in eukaryotic cells. The metabolic interconversions of these phospholipids are …