The simplistic image of the bacterium as an isolated, planktonic, self-cloning automaton is
refuted. We now recognize bacteria as microorganisms of enormous diversity and …

Routinely screened antibody fragments usually require further in vitro maturation to achieve
the desired biophysical properties. Blind in vitro strategies can produce improved ligands by …

Understanding allostery in enzymes and tools to identify it offer promising alternative
strategies to inhibitor development. Through a combination of equilibrium and …

Stenotrophomonas maltophilia is a Gram-negative, nonfermenting, environmental bacillus
that is an important cause of nosocomial infections, primarily associated with the respiratory …

β-Lactamases inactivate β-lactam antibiotics and are a major cause of antibiotic resistance.
The recent outbreaks of Klebsiella pneumoniae carbapenem resistant (KPC) infections …

ABSTRACT β-Lactamase production is the major β-lactam resistance mechanism in Gram-
negative bacteria. β-Lactamase inhibitors (BLIs) efficacious against serine β-lactamase …

CTX-M β-lactamases are prevalent antibiotic resistance enzymes and are notable for their
ability to rapidly hydrolyze the extended-spectrum cephalosporin, cefotaxime. We …

Gram-negative bacteria expressing class A β-lactamases pose a serious health threat due to
their ability to inactivate all β-lactam antibiotics. The acyl–enzyme intermediate is a central …

With few exceptions, all living organisms encode the same 20 canonical amino acids;
however, it remains an open question whether organisms with additional amino acids …

Nipah virus targets human endothelial cells via NiV-F and NiV-G envelope glycoproteins,
resulting in endothelial syncytia formation and vascular compromise. Endothelial cells …