MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy
J Matuszyk - Molecular Medicine, 2022 - Springer
Background The active metabolite of 5-Fluorouracil (5FU), used in the treatment of several
types of cancer, acts by inhibiting the thymidylate synthase encoded by the TYMS gene …
types of cancer, acts by inhibiting the thymidylate synthase encoded by the TYMS gene …
The emerging roles of N6-methyladenosine RNA methylation in human cancers
H Shen, Y Lan, Y Zhao, Y Shi, J Jin, W Xie - Biomarker Research, 2020 - Springer
Abstract N6-methyladenosine (m 6 A) is the most abundant form of mRNA modification in
eukaryotes. It affects various aspects of RNA metabolism, including nuclear export …
eukaryotes. It affects various aspects of RNA metabolism, including nuclear export …
Immune signature of T follicular helper cells predicts clinical prognostic and therapeutic impact in lung squamous cell carcinoma
F Xu, H Zhang, J Chen, L Lin, Y Chen - International immunopharmacology, 2020 - Elsevier
Lung cancer is the leading reason of cancer-related death from cancer globally for both men
and women. Recently, tumor immune heterogeneity has been implicated in cancer clinical …
and women. Recently, tumor immune heterogeneity has been implicated in cancer clinical …
m6A‐and immune‐related lncRNA signature confers robust predictive power for immune efficacy in lung squamous cell carcinoma
Z Ding, Y Liu, Q Huang, C Cheng, L Song, C Zhang… - View, 2023 - Wiley Online Library
Immune checkpoint blockade has revolutionized immunotherapy of lung squamous cell
carcinoma (LUSC), but the effective rate is less than 30% attributing to no effective and …
carcinoma (LUSC), but the effective rate is less than 30% attributing to no effective and …
Identification of susceptibility pathways for the role of chromosome 15q25. 1 in modifying lung cancer risk
Genome-wide association studies (GWAS) identified the chromosome 15q25. 1 locus as a
leading susceptibility region for lung cancer. However, the pathogenic pathways, through …
leading susceptibility region for lung cancer. However, the pathogenic pathways, through …
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data
C Mo, L Gao, X Zhu, K Wei, J Zeng, G Chen… - Cancer cell …, 2017 - Springer
Background Ubiquitin-conjugating enzyme E2C (UBE2C) has been previously reported to
correlate with the malignant progression of various human cancers, however, the exact …
correlate with the malignant progression of various human cancers, however, the exact …
Analysis of differential expression profile of miRNA in peripheral blood of patients with lung cancer
Q He, Y Fang, F Lu, J Pan, L Wang… - Journal of clinical …, 2019 - Wiley Online Library
Purpose To identify potential molecular targets for lung cancer intervention and diagnosis,
we analyzed the differential miRNA expression of peripheral blood between lung cancer …
we analyzed the differential miRNA expression of peripheral blood between lung cancer …
H3K27ac‐activated LINC00519 promotes lung squamous cell carcinoma progression by targeting miR‐450b‐5p/miR‐515‐5p/YAP1 axis
P Ye, X Lv, R Aizemaiti, J Cheng, P Xia, M Di - Cell proliferation, 2020 - Wiley Online Library
ABSTRACT Objectives Long non‐coding RNAs (lncRNAs) are extensively reported as
participants in the biological process of diverse malignancies, including lung squamous cell …
participants in the biological process of diverse malignancies, including lung squamous cell …
Investigation of miR-136-5p key target genes and pathways in lung squamous cell cancer based on TCGA database and bioinformatics analysis
Background Lung squamous cell cancer (LUSC) is a common but challenging malignancy. It
is important to illuminate the molecular mechanism of LUSC. Thus, we aim to explore the …
is important to illuminate the molecular mechanism of LUSC. Thus, we aim to explore the …
MiR-182-5p and its target HOXA9 in non-small cell lung cancer: a clinical and in-silico exploration with the combination of RT-qPCR, miRNA-seq and miRNA-chip
L Gao, S Yan, J Yang, J Kong, K Shi, F Ma… - BMC medical …, 2020 - Springer
Abstract Background MiR-182-5p, a cancer-related microRNA (miRNA), modulates
tumorigenesis and patient outcomes in various human malignances. This study interroted …
tumorigenesis and patient outcomes in various human malignances. This study interroted …