The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

G Burgstaller, B Oehrle, M Gerckens… - European …, 2017 - Eur Respiratory Soc
The pulmonary extracellular matrix (ECM) determines the tissue architecture of the lung, and
provides mechanical stability and elastic recoil, which are essential for physiological lung …

[HTML][HTML] A review of cellularization strategies for tissue engineering of whole organs

ME Scarritt, NC Pashos, BA Bunnell - Frontiers in bioengineering and …, 2015 - frontiersin.org
With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for
organ engineering were generated from numerous tissues, including the heart, lung, liver …

The host response to naturally-derived extracellular matrix biomaterials

AH Morris, DK Stamer, TR Kyriakides - Seminars in immunology, 2017 - Elsevier
Biomaterials based on natural materials including decellularized tissues and tissue-derived
hydrogels are becoming more widely used for clinical applications. Because of their native …

Acellular human lung scaffolds to model lung disease and tissue regeneration

SE Gilpin, DE Wagner - European Respiratory Review, 2018 - Eur Respiratory Soc
Recent advances in whole lung bioengineering have opened new doors for studying lung
repair and regeneration ex vivo using acellular human derived lung tissue scaffolds …

How to build a lung: latest advances and emerging themes in lung bioengineering

MM De Santis, DA Bölükbas… - European …, 2018 - Eur Respiratory Soc
Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide.
The only option at end-stage disease is lung transplantation, but there are not enough donor …

[HTML][HTML] Lung microvascular niche, repair, and engineering

T Tsuchiya, R Doi, T Obata, G Hatachi… - … in Bioengineering and …, 2020 - frontiersin.org
Biomaterials have been used for a long time in the field of medicine. Since the success of
“tissue engineering” pioneered by Langer and Vacanti in 1993, tissue engineering studies …

Revascularization of decellularized lung scaffolds: principles and progress

CT Stabler, S Lecht, MJ Mondrinos… - … of Physiology-Lung …, 2015 - journals.physiology.org
There is a clear unmet clinical need for novel biotechnology-based therapeutic approaches
to lung repair and/or replacement, such as tissue engineering of whole bioengineered …

Re‐endothelialization of rat lung scaffolds through passive, gravity‐driven seeding of segment‐specific pulmonary endothelial cells

ME Scarritt, NC Pashos, JM Motherwell… - Journal of tissue …, 2018 - Wiley Online Library
Effective re‐endothelialization is critical for the use of decellularized scaffolds for ex vivo
lung engineering. Current approaches yield insufficiently re‐endothelialized scaffolds that …

Comparative proteomic analyses of human adipose extracellular matrices decellularized using alternative procedures

C Thomas‐Porch, J Li, F Zanata… - … research Part A, 2018 - Wiley Online Library
Decellularized human adipose tissue has potential clinical utility as a processed biological
scaffold for soft tissue cosmesis, grafting, and reconstruction. Adipose tissue …

Characterization of an acellular scaffold for a tissue engineering approach to the nipple-areolar complex reconstruction

NC Pashos, ME Scarritt, ZR Eagle, JM Gimble… - Cells Tissues …, 2017 - karger.com
A significant number of patients undergo mastectomies and breast reconstructions every
year using many surgical-based techniques to reconstruct the nipple-areolar complex …