Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Phytochemicals have a long and successful history in drug discovery. With recent
advancements in analytical techniques and methodologies, discovering bioactive leads from …

Native mass spectrometry has recently moved alongside traditional structural biology
techniques in its ability to provide clear insights into the composition of protein complexes …

Long noncoding RNAs (lncRNAs) are usually 5′ capped and 3′ polyadenylated, similar to
most typical mRNAs. However, recent studies revealed a type of snoRNA-related lncRNA …

Recent work in structural biology is shedding light on how many of the enzymes of
intermediary metabolism are self-and co-assembling into large, filamentous polymers or …

Integrative modeling is an increasingly important tool in structural biology, providing
structures by combining data from varied experimental methods and prior information. As a …

Highlights•Allosteric signals underlie the functional mechanisms of allosteric
drugs.•Elucidation of allosteric signals facilitates rational allosteric drug discovery.• …

The majority of processes that occur in daily cell life are modulated by hundreds to
thousands of dynamic protein–protein interactions (PPI). The resulting protein complexes …

In the last 20 years, the use of electron paramagnetic resonance (EPR) has made a
pronounced and lasting impact in the field of structural biology. The advantage of EPR …

Distance determination with pulsed EPR has become an important technique for the
structural investigation of biomacromolecules, with double electron–electron resonance …