There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

Heart disease is a leading cause of death worldwide. In many forms of heart disease,
including heart failure, ischaemic heart disease and diabetic cardiomyopathies, changes in …

Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …

Ischemic heart disease and heart failure are leading causes of mortality and morbidity
worldwide. They continue to be major burden on health care systems throughout the world …

Malonylation is a recently identified post-translational modification with malonyl-coenzyme A
as the donor. It conserved both in prokaryotes and eukaryotes. Recent advances in the …

Rationale: Fatty acid oxidation is transcriptionally regulated by peroxisome proliferator–
activated receptor (PPAR) α and under normal conditions accounts for 70% of cardiac ATP …

Ischemic heart disease refers to myocardial degeneration, necrosis, and fibrosis caused by
coronary artery disease. It can lead to severe left ventricular dysfunction (LVEF≤ 35–40%) …

The shift in substrate preference away from fatty acid oxidation (FAO) towards increased
glucose utilization in heart failure has long been interpreted as an oxygen-sparing …

Cardiovascular diseases are accompanied by disorders in the cardiac metabolism.
Furthermore, comorbidities often associated with cardiovascular disease can alter systemic …

The pyridine nucleotides NAD+ and NADP+ play a pivotal role in regulating intermediary
metabolism in the heart. The intracellular NAD+/NADH ratio controls flux through various …