Personalized medicine: motivation, challenges, and progress

LH Goetz, NJ Schork - Fertility and sterility, 2018 - Elsevier
There is a great deal of hype surrounding the concept of personalized medicine.
Personalized medicine is rooted in the belief that since individuals possess nuanced and …

Obesity, inflammation, and cancer

T Deng, CJ Lyon, S Bergin, MA Caligiuri… - Annual Review of …, 2016 - annualreviews.org
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including cancer, and is increasingly recognized as a growing cause of preventable cancer …

Air pollution, genetic factors, and the risk of lung cancer: a prospective study in the UK Biobank

Y Huang, M Zhu, M Ji, J Fan, J Xie, X Wei… - American journal of …, 2021 - atsjournals.org
Rationale: Both genetic and environmental factors contribute to lung cancer, but the degree
to which air pollution modifies the impact of genetic susceptibility on lung cancer remains …

Aspirin and colorectal cancer: the promise of precision chemoprevention

DA Drew, Y Cao, AT Chan - Nature Reviews Cancer, 2016 - nature.com
Aspirin (acetylsalicylic acid) has become one of the most commonly used drugs, given its
role as an analgesic, antipyretic and agent for cardiovascular prophylaxis. Several decades …

Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents

XR Xu, GM Yousef, H Ni - Blood, The Journal of the American …, 2018 - ashpublications.org
Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …

Interventional gastroenterology in oncology

V Wadhwa, N Patel, D Grover, FS Ali… - CA: A Cancer Journal …, 2023 - Wiley Online Library
Cancer is one of the foremost health problems worldwide and is among the leading causes
of death in the United States. Gastrointestinal tract cancers account for almost one third of …

[HTML][HTML] Aspirin and the risk of colorectal and other digestive tract cancers: an updated meta-analysis through 2019

C Bosetti, C Santucci, S Gallus, M Martinetti… - Annals of oncology, 2020 - Elsevier
Background Aspirin has been associated with a reduced risk of colorectal cancer, and
possibly of a few other digestive tract cancers. The quantification of risk reduction and the …

Determining risk of colorectal cancer and starting age of screening based on lifestyle, environmental, and genetic factors

J Jeon, M Du, RE Schoen, M Hoffmeister, PA Newcomb… - Gastroenterology, 2018 - Elsevier
Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …

Chemoprevention of colorectal cancer

BW Katona, JM Weiss - Gastroenterology, 2020 - Elsevier
Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from
CRC, chemoprevention strategies have the potential to further reduce CRC incidence and …

Population-wide impact of long-term use of aspirin and the risk for cancer

Y Cao, R Nishihara, K Wu, M Wang, S Ogino… - JAMA …, 2016 - jamanetwork.com
Importance The US Preventive Services Task Force recently recommended the use of
aspirin to prevent colorectal cancer and cardiovascular disease among many US adults …