Alternatives to conventional antibiotics in the era of antimicrobial resistance

C Ghosh, P Sarkar, R Issa, J Haldar - Trends in microbiology, 2019 - cell.com
As more antibiotics are rendered ineffective by drug-resistant bacteria, focus must be shifted
towards alternative therapies for treating infections. Although several alternatives already …

Antimicrobial peptides: interaction with model and biological membranes and synergism with chemical antibiotics

A Hollmann, M Martinez, P Maturana… - Frontiers in …, 2018 - frontiersin.org
Antimicrobial peptides (AMPs) are promising novel antibiotics since they have shown
antimicrobial activity against a wide range of bacterial species, including multiresistant …

Addressing MRSA infection and antibacterial resistance with peptoid polymers

J Xie, M Zhou, Y Qian, Z Cong, S Chen… - Nature …, 2021 - nature.com
Abstract Methicillin-Resistant Staphylococcus aureus (MRSA) induced infection calls for
antibacterial agents that are not prone to antimicrobial resistance. We prepare protease …

Antibiotic hybrids: the next generation of agents and adjuvants against Gram-negative pathogens?

R Domalaon, T Idowu, GG Zhanel… - Clinical microbiology …, 2018 - Am Soc Microbiol
The global incidence of drug-resistant Gram-negative bacillary infections has been
increasing, and there is a dire need to develop novel strategies to overcome this problem …

Structure–activity relationship of cationic surfactants as antimicrobial agents

C Zhou, Y Wang - Current Opinion in Colloid & Interface Science, 2020 - Elsevier
Cationic surfactants are widely used as antimicrobial agents in various fields. However, the
widespread use of cationic surfactants has caused huge accumulation in environment …

Recent progress in polymer research to tackle infections and antimicrobial resistance

MM Konai, B Bhattacharjee, S Ghosh… - …, 2018 - ACS Publications
Global health is increasingly being threatened by the rapid emergence of drug-resistant
microbes. The ability of these microbes to form biofilms has further exacerbated the scenario …

Synergy by perturbing the gram-negative outer membrane: opening the door for gram-positive specific antibiotics

CMJ Wesseling, NI Martin - ACS Infectious Diseases, 2022 - ACS Publications
New approaches to target antibacterial agents toward Gram-negative bacteria are key, given
the rise of antibiotic resistance. Since the discovery of polymyxin B nonapeptide as a potent …

Biodegradable cationic and ionizable cationic lipids: A roadmap for safer pharmaceutical excipients

AM Jörgensen, R Wibel, A Bernkop‐Schnürch - Small, 2023 - Wiley Online Library
Cationic and ionizable cationic lipids are broadly applied as auxiliary agents, but their use is
associated with adverse effects. If these excipients are rapidly degraded to endogenously …

Selective antimicrobial activities and action mechanism of micelles self-assembled by cationic oligomeric surfactants

C Zhou, F Wang, H Chen, M Li, F Qiao… - … applied materials & …, 2016 - ACS Publications
This work reports that cationic micelles formed by cationic trimeric, tetrameric, and
hexameric surfactants bearing amide moieties in spacers can efficiently kill Gram-negative …

Small molecular mimetics of antimicrobial peptides as a promising therapy to combat bacterial resistance

P Teng, H Shao, B Huang, J Xie, S Cui… - Journal of Medicinal …, 2023 - ACS Publications
Clinically, antibiotics are widely used to treat infectious diseases; however, excessive drug
abuse and overuse exacerbate the prevalence of drug-resistant bacterial pathogens …