The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …

Abstract Background The World Health Organization (WHO) Classification of Tumours, also
known as WHO Blue Books, represents an international standardised tool in the diagnostic …

The World Health Organization (WHO) central nervous system tumor classification
represents the primary source of updates on diagnostic classes, grades and criteria [17] …

Telomeres maintain genomic integrity in normal cells, and their progressive shortening
during successive cell divisions induces chromosomal instability. In the large majority of …

Most high-grade meningiomas show a highly perturbed copy number profile and they are
enriched for TERT promoter mutations [6, 7, 11, 12]. In addition, homozygous focal deletions …

Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …

EGFR amplification (EGFR amp), the combination of gain of chromosome 7 and loss of
chromosome 10 (7+/10−), and TERT promoter mutation (p TERT mut) are alterations …

Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …

Solitary fibrous tumors are an uncommon sarcoma type characterized by NAB2–STAT6
gene fusion. While solitary fibrous tumors metastasize in 5–25% of cases, it has historically …