Lysophospholipid mediators in health and disease

K Kano, J Aoki, T Hla - Annual Review of Pathology …, 2022 - annualreviews.org
Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-
phosphate (S1P), are produced by the metabolism and perturbation of biological …

Two pathways for lysophosphatidic acid production

J Aoki, A Inoue, S Okudaira - … et Biophysica Acta (BBA)-Molecular and Cell …, 2008 - Elsevier
Lysophosphatidic acid (LPA, 1-or 2-acyl-sn-glycerol 3-phosphate) is a simple phospholipid
but displays an intriguing cell biology that is mediated via interactions with G protein …

The sheep genome illuminates biology of the rumen and lipid metabolism

Y Jiang, M Xie, W Chen, R Talbot, JF Maddox, T Faraut… - Science, 2014 - science.org
Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and
represent a distinct class of animals that have a specialized digestive organ, the rumen, that …

Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing

N Chen, X Xia, Q Hanif, F Zhang, R Dang… - Nature …, 2023 - nature.com
Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral
communities across a wide range of agro-ecosystems, from extremely hot semiarid regions …

Lysophosphatidic acid as a lipid mediator with multiple biological actions

S Aikawa, T Hashimoto, K Kano… - The journal of …, 2015 - academic.oup.com
Lysophosphatidic acid (LPA) is one of the simplest glycerophospholipids with one fatty acid
chain and a phosphate group as a polar head. Although LPA had been viewed just as a …

G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

SM Pasternack, I von Kügelgen, KA Aboud, YA Lee… - Nature …, 2008 - nature.com
Hypotrichosis simplex is a group of nonsyndromic human alopecias. We mapped an
autosomal recessive form of this disorder to chromosome 13q14. 11–13q21. 33, and …

Autotaxin and LPA receptor signaling in cancer

AJS Houben, WH Moolenaar - Cancer and Metastasis Reviews, 2011 - Springer
Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that
functions as a mitogen and motility factor for many cell types. LPA signals through six …

Variant PADI3 in Central Centrifugal Cicatricial Alopecia

L Malki, O Sarig, MT Romano, MC Méchin… - … England Journal of …, 2019 - Mass Medical Soc
Background Central centrifugal cicatricial alopecia (CCCA) is the most common form of
scarring alopecia among women of African ancestry. The disease is occasionally observed …

Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6

K Yanagida, K Masago, H Nakanishi, Y Kihara… - Journal of Biological …, 2009 - ASBMB
p2y5 is an orphan G protein-coupled receptor that is closely related to the fourth
lysophosphatidic acid (LPA) receptor, LPA 4. Here we report that p2y5 is a novel LPA …

Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6

R Taniguchi, A Inoue, M Sayama, A Uwamizu… - Nature, 2017 - nature.com
Lysophosphatidic acid (LPA) is a bioactive lipid composed of a phosphate group, a glycerol
backbone, and a single acyl chain that varies in length and saturation. LPA activates six …