Lag is a temporary period of nonreplication seen in bacteria that are introduced to new
media. Despite latency being described by Müller in 1895, only recently have we gained …

Microbial drug persistence is a widespread phenomenon in which a subpopulation of
microorganisms is able to survive antimicrobial treatment without acquiring resistance …

Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state
and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus …

Antimicrobial efficacy, which is central to many aspects of medicine, is being rapidly eroded
by bacterial resistance. Since new resistance can be induced by antimicrobial action, highly …

The potentiation of antibiotics is a promising strategy for combatting antibiotic-
resistant/tolerant bacteria. Herein, we report that a 5-min sublethal heat shock enhances the …

Deeper understanding of antibiotic-induced physiological responses is critical to identifying
means for enhancing our current antibiotic arsenal. Bactericidal antibiotics with diverse …

Highlights•Lethal antimicrobial stress triggers accumulation of reactive oxygen species
(ROS).•The stress-mediated ROS cascade and its effects are controlled in multiple ways.•At …

Prolonged antibiotic treatment can lead to detrimental side effects in patients, including
ototoxicity, nephrotoxicity, and tendinopathy, yet the mechanisms underlying the effects of …

The brain is a major metabolizer of oxygen and yet has relatively feeble protective
antioxidant mechanisms. This paper reviews the Janus‐faced properties of reactive oxygen …

Bactericidal antibiotics kill by modulating their respective targets. This traditional view has
been challenged by studies that propose an alternative, unified mechanism of killing …