The specificity of RNA silencing is conferred by small RNA guides that are processed from
structured RNA or dsRNA. The core components for small RNA biogenesis and effector …

The four mammalian Argonaute family members are thought to share redundant functions in
the microRNA pathway, yet only AGO2 possesses the catalytic" slicer" function required for …

Argonaute protein (AGO)-associated small RNAs, which include microRNAs and
endogenous small RNAs, are important post-transcriptional regulators of gene expression in …

Small RNA-mediated gene silencing is an ancient, evolutionarily conserved and only
recently discovered gene regulatory mechanism. This thesis is aimed towards …

Ribonuclease activity within the RNAi mechanism has been thoroughly described in model
organisms such as Caenorhabditis elegans. However, RNAi is still largely a mystery in …

RNA interference is a naturally occurring process of gene silencing that reduces the
expression of the gene from which the RNA sequence is derived, when added in a double …

During mitosis, some cellular contents can be distributed randomly, whereas others must be
distributed evenly between daughter cells. For example, components of the transforming …

RNA silencing pathways are required for a wide variety of processes in most eucaryotes. In
plants, small-interfering RNA (siRNA) arising from transposons and other repetitive …