Anhedonia is considered a core feature of major depressive disorder, and the dopamine
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …

Depression is linked to deficits in cognitive control and a host of other cognitive impairments
arise as a consequence of these deficits. Despite of their important role in depression, there …

Objective: Loss of pleasure or interest in activities (ie, anhedonia) is a risk factor for
suicidality, treatment nonresponse, and relapse. Extant treatments that focus on reducing …

The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …

Background Many depressed patients are not able to achieve or sustain symptom remission
despite serial treatment trials–often termed “treatment resistant depression”. A broader …

Depression is characterized by increased levels of negative affect and decreased levels of
positive affect. Prior research shows that individual differences in emotion regulation play an …

Anhedonia, or loss of interest or pleasure in usual activities, is characteristic of depression,
some types of anxiety, as well as substance abuse and schizophrenia. Anhedonia is a …

There has been a marked increase of network studies of Major Depressive Disorder (MDD).
Despite rapidly growing contributions, their findings have yet to be systematically …

Depression is a significant public health problem, but its etiology and pathophysiology
remain poorly understood. Such incomplete understanding likely arises from the fact that …

Despite numerous studies on the neurobiology of depression, the etiological and
pathophysiological mechanisms of this disorder remain poorly understood. A large number …