Tissue development and homeostasis are regulated by opposing pro-survival and pro-death
signals. An interesting feature of the Tumor Necrosis Factor (TNF) family of ligands is that …

Immune sentinel cells initiate immune responses to pathogens and tissue injury and are
capable of producing highly stimulus-specific responses. Insight into the mechanisms …

Large-scale analysis of cellular response to anticancer drugs typically focuses on variation
in potency (half-maximum inhibitory concentration,(IC50)), assuming that it is the most …

In response to tumor necrosis factor (TNF), NF-κB enters the nucleus and promotes
inflammatory and stress-responsive gene transcription. Because NF-κB deregulation is …

Mathematical equations are fundamental to modeling biological networks, but as networks
get large and revisions frequent, it becomes difficult to manage equations directly or to …

The mechanical stiffness of a cell's environment exerts a strong, but variable, influence on
cell behavior and fate. For example, different cell types cultured on compliant substrates …

Autophagy regulates cell death both positively and negatively, but the molecular basis for
this paradox remains inadequately characterized. We demonstrate here that transient cell-to …

Fractional killing is the main cause of tumour resistance to chemotherapy. This phenomenon
is observed even in genetically identical cancer cells in homogeneous microenvironments …

Signal transduction networks allow eukaryotic cells to make decisions based on information
about intracellular state and the environment. Biochemical noise significantly diminishes the …

When cells are exposed to death ligands such as TRAIL, a fraction undergoes apoptosis
and a fraction survives; if surviving cells are re‐exposed to TRAIL, fractional killing is once …