The use of antimalarial drugs against viral infection

S D'Alessandro, D Scaccabarozzi, L Signorini… - Microorganisms, 2020 - mdpi.com
In recent decades, drugs used to treat malaria infection have been shown to be beneficial for
many other diseases, including viral infections. In particular, they have received special …

Beyond malaria: The inhibition of viruses by artemisinin-type compounds

T Efferth - Biotechnology advances, 2018 - Elsevier
Natural products represent valuable chemical scaffolds for drug development. A recent
success story in this context was artemisinin, which is not only active against malaria but …

Recent pharmacological advances in the repurposing of artemisinin drugs

Y Meng, N Ma, H Lyu, YK Wong… - Medicinal research …, 2021 - Wiley Online Library
Artemisinins are a family of sesquiterpene lactones originally derived from the sweet
wormwood (Artemisia annua). Beyond their well‐characterized role as frontline antimalarial …

Machine learning models identify inhibitors of SARS-CoV-2

VO Gawriljuk, PPK Zin, AC Puhl, KM Zorn… - Journal of chemical …, 2021 - ACS Publications
With the rapidly evolving SARS-CoV-2 variants of concern, there is an urgent need for the
discovery of further treatments for the coronavirus disease (COVID-19). Drug repurposing is …

Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and In Situ Hybridization

M Holdhoff, G Guner, FJ Rodriguez, JL Hicks… - Clinical Cancer …, 2017 - AACR
Purpose: Reports of cytomegalovirus (CMV) detection in high-grade gliomas
(HGG)/glioblastoma have been conflicting. We undertook a comprehensive approach to …

Use of artesunate in non-malarial indications

A Raffetin, F Bruneel, C Roussel, M Thellier… - Medecine et maladies …, 2018 - Elsevier
Introduction Artesunate and other artemisinin derivatives are used in various infectious and
non-infectious diseases. We aimed to analyze available data on artesunate and artemisinin …

Cytomegalovirus kinetics following primary infection in healthy women

MS Forman, D Vaidya, O Bolorunduro… - The Journal of …, 2017 - academic.oup.com
The kinetics of cytomegalovirus (CMV) DNA in infected asymptomatic hosts are largely
unknown. We measured viral load (VL) in 124 fluid samples (oral, urine, vaginal, blood) …

Real-world evidence to assess medication safety or effectiveness in children: systematic review

T Lasky, B Carleton, DB Horton, LE Kelly… - Drugs-Real World …, 2020 - Springer
Background The promise of real-world evidence (RWE) is especially relevant to pediatrics,
where medicines prescribed for children are often used without evidence derived from …

Ganciclovir‐resistant cytomegalovirus infection in abdominal solid organ transplant recipients: case series and review of the literature

KE Rolling, MR Jorgenson… - … : The Journal of …, 2017 - Wiley Online Library
Ganciclovir‐resistant cytomegalovirus (GR‐CMV) is emerging as a significant infection in the
abdominal transplant population. GR‐CMV is difficult to manage, and treatment options are …

Artesunate-derived monomeric, dimeric and trimeric experimental drugs–Their unique mechanistic basis and pronounced antiherpesviral activity

F Hahn, T Fröhlich, T Frank, LD Bertzbach, S Kohrt… - Antiviral Research, 2018 - Elsevier
Human cytomegalovirus (HCMV) is a major human pathogen and is associated with severe
pathology, such as life-threatening courses of infection in immunocompromised individuals …