ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical …
K Ye, Z Chen, Y Xu - Cell Death & Disease, 2023 - nature.com
Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it has been implicated in the pathogenesis of many diseases, there is evidence to support that …
WP Roos, AD Thomas, B Kaina - Nature Reviews Cancer, 2016 - nature.com
DNA is vulnerable to damage resulting from endogenous metabolites, environmental and dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …
H Blaser, C Dostert, TW Mak, D Brenner - Trends in cell biology, 2016 - cell.com
Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and …
Necroptosis is a form of regulated cell death that critically depends on receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and …
TV Berghe, A Linkermann, S Jouan-Lanhouet… - … reviews Molecular cell …, 2014 - nature.com
Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein …
The NF-κB family of inducible transcription factors is activated in response to a variety of stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …
D Brenner, H Blaser, TW Mak - Nature Reviews Immunology, 2015 - nature.com
Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) …